What is Semaglutide?

Doctors primarily prescribe semaglutide to manage type 2 diabetes, aid weight loss in specific patients, and reduce the risk of major cardiovascular events like heart attacks or strokes. Available under the brand names Ozempic, Wegovy, and Rybelsus, semaglutide belongs to a class called GLP-1 receptor agonists. It works by enhancing insulin release, lowering glucagon levels, delaying gastric emptying, and reducing appetite.

Semaglutide for Weight Loss and Diabetes

Among these medications, Wegovy is the only brand FDA-approved for weight loss. Ozempic and Wegovy are administered via weekly subcutaneous injections, while Rybelsus comes as a daily oral tablet. Semaglutide is not intended for individuals with type 1 diabetes and is available solely as branded prescriptions, manufactured by Novo Nordisk.

Key Differences: Ozempic, Wegovy, and Rybelsus

– Ozempic: Used to lower blood sugar in type 2 diabetes patients and reduce cardiovascular risks. Given as a weekly injection alongside diet and exercise.
– Wegovy: Focused on weight management, it also reduces cardiovascular risk. Similar to Ozempic, patients inject it weekly
– Rybelsus: A daily oral tablet taken 30 minutes before food, used to manage blood sugar levels in type 2 diabetes patients.

How Does Semaglutide Work?

Semaglutide helps control high blood sugar and appetite by increasing insulin production, reducing glucagon levels, and slowing digestion. These mechanisms contribute to better weight and blood sugar control.

Side Effects of Semaglutide

Common side effects include nausea, stomach pain, vomiting, diarrhea, constipation, and low blood sugar for diabetes patients. Serious side effects can include kidney issues, gallbladder disease, pancreatitis, vision changes, and allergic reactions. Seek immediate medical attention for symptoms such as severe abdominal pain, swelling in the neck, or difficulty breathing.

Dosage and Administration Tips

– Ozempic and Wegovy: Injected once weekly, ideally on the same day. Ozempic pens offer different dose options.
– Rybelsus: Taken once daily, at least 30 minutes before any food or drink, with only plain water.

Note: Consult your healthcare provider for specific dosing instructions and if transitioning between medications.

Storage Instructions

– Keep Ozempic and Wegovy refrigerated until the first use. Afterwards, they can be stored at room temperature.
– Rybelsus: Keep tablets in their original container away from moisture.

Active and Inactive Ingredients

– Ozempic: Contains disodium phosphate dihydrate, propylene glycol, phenol, and water.
– Wegovy: Includes disodium phosphate dihydrate and sodium chloride.
– Rybelsus: Comprises magnesium stearate, microcrystalline cellulose, and SNAC.

Manufacturer Information

Novo Nordisk A/S in Denmark manufactures all semaglutide medications, including Ozempic, Wegovy, and Rybelsus.